LAS1L antibody (AA 200-250)

Catalog No. ABIN7454509

The Rabbit Polyclonal anti-LAS1L antibody has been validated for IP and IHC (fp). It is suitable to detect LAS1L in samples from Human.

Quick Overview for LAS1L antibody (AA 200-250) (ABIN7454509)

Target: LAS1L (LAS1-Like (LAS1L))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LAS1L antibody is un-conjugated

Application: Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Product Details anti-LAS1L Antibody

Binding Specificity: AA 200-250

Purpose: Rabbit anti-LAS1L Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: Between AA 200 and 250

Isotype: IgG

Application Details

Application Notes:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: Not recommended

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for LAS1L

Target: LAS1L (LAS1-Like (LAS1L))

Alternative Name: LAS1L

Background: Background: LAS1L is involved in the biogenesis of the 60S ribosomal subunit. It is required for maturation of the 28S rRNA. LAS1L functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex, the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes [taken from the Universal Protein Resource (UniProt) Q9Y4W2].

Gene ID: 81887

NCBI Accession: NP_112483

UniProt: Q9Y4W2