NMNAT1 antibody (AA 229-279)

Catalog No. ABIN7454578

The Rabbit Polyclonal anti-NMNAT1 antibody has been validated for WB and IHC (fp). It is suitable to detect NMNAT1 in samples from Human and Mouse.

Quick Overview for NMNAT1 antibody (AA 229-279) (ABIN7454578)

Target: NMNAT1 (Nicotinamide Nucleotide Adenylyltransferase 1 (NMNAT1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NMNAT1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Product Details anti-NMNAT1 Antibody

Binding Specificity: AA 229-279

Purpose: Rabbit anti-NMNAT1 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: Between AA 229 and 279

Isotype: IgG

Application Details

Application Notes:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: Not recommended

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for NMNAT1

Target: NMNAT1 (Nicotinamide Nucleotide Adenylyltransferase 1 (NMNAT1))

Alternative Name: NMNAT1

Background: Background: Nicotinamide mononucleotide adenylyltransferase 1 (NMNAT1) catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. NMNAT1 is an enzyme which catalyzes a key step in the biosynthesis of the coenzyme NAD. NMNAT1 is one of several nicotinamide nucleotide adenylyltransferases. Studies in Drosophila and mammalian neurons have shown NMNAT1 can confer protection to damaged neurons. This protection requires enzymatic activity which increases NAD levels and activates a nuclear deacetylase which is the protective molecul [taken from NCBI Entrez Gene (Gene ID: 64802)].

Gene ID: 64802

NCBI Accession: NP_073624

UniProt: Q9HAN9