PARP10 antibody (AA 300-350)

Catalog No. ABIN7454656

The Rabbit Polyclonal anti-PARP10 antibody is suitable to detect PARP10 in samples from Human. It has been validated for WB, IP and IHC (fp).

Quick Overview for PARP10 antibody (AA 300-350) (ABIN7454656)

Target: PARP10 (Poly (ADP-Ribose) Polymerase Family, Member 10 (PARP10))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PARP10 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Product Details anti-PARP10 Antibody

Binding Specificity: AA 300-350

Purpose: Rabbit anti-PARP10 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 300 and 350

Isotype: IgG

Application Details

Application Notes:

IHC: 1:500 to 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: 1:2,000: 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for PARP10

Target: PARP10 (Poly (ADP-Ribose) Polymerase Family, Member 10 (PARP10))

Alternative Name: PARP10

Background: Background: PARP10 is a member of the poly(ADP-ribose) polymerase (PARP) family involved in a variety of processes which includes DNA metabolism, the DNA damage response, transcription and the maintenance of genomic stability. Although each member of the PARP family exhibits poly(ADP-ribose) polymerase activity which catalyzes the attachment of ADP-ribose units from NAD+ to substrate proteins, the endogenous substrates of many of the family members, including PARP10, remain to be identified. Recent studies have shown that PARP10 is localized to the nucleoli and associates with RNA polymerase II. PARP10 is a substrate of and is activated by CDK2 and may serve an important function in cell proliferation.

Gene ID: 84875

NCBI Accession: NP_116178

UniProt: Q53GL7