TIMELESS antibody (C-Term)

Catalog No. ABIN7454703

This Rabbit Polyclonal antibody specifically detects TIMELESS in WB, IP and IHC (fp). It exhibits reactivity toward Human.

Quick Overview for TIMELESS antibody (C-Term) (ABIN7454703)

Target: TIMELESS (Timeless Homolog (TIMELESS))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TIMELESS antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Product Details anti-TIMELESS Antibody

Binding Specificity: C-Term

Purpose: Rabbit anti-Timeless Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 1170 and C-term

Isotype: IgG

Application Details

Application Notes:

IHC: 1:200 - 1:1,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for TIMELESS

Target: TIMELESS (Timeless Homolog (TIMELESS))

Alternative Name: Timeless

Background: Background: Timeless was first identified in Drosophila as a transcriptional regulator involved in the fly circadian rhythm. In mice, humans and yeast, the homologs of drosophila timeless have been observed to play a role in the DNA damage checkpoint response. Human timeless has been shown to interact with the circadian clock protein cryptochrome 2 as well as the DNA checkpoint proteins Chk1 and the ATR-ATRIP complex suggesting a link between circadian rhythm and the cell cycle.

Gene ID: 8914

NCBI Accession: NP_003911

UniProt: Q9UNS1

Pathways: Protein targeting to Nucleus, Photoperiodism