FLCN antibody (AA 1-50)

Catalog No. ABIN7454827

The Rabbit Polyclonal anti-FLCN antibody has been validated for WB, IP and IHC (fp). It is suitable to detect FLCN in samples from Human.

Quick Overview for FLCN antibody (AA 1-50) (ABIN7454827)

Target: FLCN (Folliculin (FLCN))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FLCN antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Product Details anti-FLCN Antibody

Binding Specificity: AA 1-50

Purpose: Rabbit anti-BHD Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 1 and 50

Isotype: IgG

Application Details

Application Notes:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for FLCN

Target: FLCN (Folliculin (FLCN))

Alternative Name: BHD

Target Type: Amino Acid

Background: Background: Defects in the folliculin (FLCN) gene are the cause of Birt-Hogg-Dube syndrome (BHD) [MIM:135150]. BHD is a rare autosomal dominant genodermatosis characterized by hair follicle hamartomas (fibrofolliculomas), kidney tumors, and spontaneous pneumothorax. Fibrofolliculomas are part of the triad of BHD skin lesions that also includes trichodiscomas and acrochordons. Defects in FLCN may also be the cause of primary spontaneous pneumothorax (PSP) [MIM:173600], a condition in which air is present in the pleural space in the absence of a precipitating event, such as trauma or lung disease. Folliculin may be a tumor suppressor involved in colorectal and renal cell tumorigenesis [taken from the Universal Protein Resource (UniProt) Q8NFG4].

Gene ID: 201163

NCBI Accession: NP_659434

UniProt: Q8NFG4

Pathways: Cell-Cell Junction Organization