CAMKK2 antibody (AA 538-588)

Catalog No. ABIN7455000

This Rabbit Polyclonal antibody specifically detects CAMKK2 in WB, IP and IHC (fp). It exhibits reactivity toward Human.

Quick Overview for CAMKK2 antibody (AA 538-588) (ABIN7455000)

Target: CAMKK2 (Calcium/calmodulin-Dependent Protein Kinase Kinase 2, beta (CAMKK2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CAMKK2 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Product Details anti-CAMKK2 Antibody

Binding Specificity: AA 538-588

Purpose: Rabbit anti-CaMKK2 Antibody, Affinity Purified

Predicted Reactivity: Rat

Purification: Affinity Purified

Immunogen: Between AA 538 and 588

Isotype: IgG

Application Details

Application Notes:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: 1:500 - 1:2,500

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for CAMKK2

Target: CAMKK2 (Calcium/calmodulin-Dependent Protein Kinase Kinase 2, beta (CAMKK2))

Alternative Name: CaMKK2

Background: Background: Calcium/calmodulin-dependent protein kinase kinase 2 belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of the CAMKK2 gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation [taken from NCBI Entrez Gene (Gene ID: 10645)].

Gene ID: 10645

NCBI Accession: NP_006540

UniProt: Q96RR4

Pathways: AMPK Signaling