Complement Factor B antibody

Catalog No. ABIN7490606

The Rabbit Chimeric anti-Complement Factor B antibody has been validated for FACS. It is suitable to detect Complement Factor B in samples from Human.

Quick Overview for Complement Factor B antibody (ABIN7490606)

Target: Complement Factor B (CFB)

Fragment: Fc fragment

Reactivity: Human

Host: Rabbit

Clonality: Chimeric

Conjugate: This Complement Factor B antibody is un-conjugated

Application: Flow Cytometry (FACS)

Product Details anti-Complement Factor B Antibody

Characteristics: Rabbit/Human Fc chimeric IgG1

Purification: Purified from cell culture supernatant by affinity chromatography

Isotype: IgG1

Application Details

Application Notes: Flow Cyt  1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details for Complement Factor B

Target: Complement Factor B (CFB)

Alternative Name: CFB

Background: AHUS4, ARMD14, BF, BFD, CFAB, CFBD, FB, FBI12, GBG, H2-Bf, PBF2
Description: This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.

UniProt: P00751

Pathways: Complement System, Proton Transport, Ribonucleoside Biosynthetic Process