POT1 antibody

Catalog No. ABIN7465387

The Rabbit Polyclonal anti-POT1 antibody has been validated for WB. It is suitable to detect POT1 in samples from Human.

Quick Overview for POT1 antibody (ABIN7465387)

Target: POT1 (Protection of Telomeres 1 (POT1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This POT1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-POT1 Antibody

Cross-Reactivity: Human

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human POT1. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: A431

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.73 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for POT1

Target: POT1 (Protection of Telomeres 1 (POT1))

Alternative Name: protection of telomeres 1

Background: Protection of telomeres 1 , CMM10 , GLM9 , HPOT1,This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described. [provided by RefSeq]

Molecular Weight: 71 kDa

Gene ID: 25913

UniProt: Q9NUX5

Pathways: Cell Division Cycle, Telomere Maintenance