MYSM1 antibody (C-Term)

Catalog No. ABIN7465962

This Rabbit Polyclonal antibody specifically detects MYSM1 in WB. It exhibits reactivity toward Human.

Quick Overview for MYSM1 antibody (C-Term) (ABIN7465962)

Target: MYSM1 (Myb-Like, SWIRM and MPN Domains 1 (MYSM1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MYSM1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MYSM1 Antibody

Binding Specificity: C-Term

Cross-Reactivity: Human

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human MYSM1. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: HeLa , HepG2

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for MYSM1

Target: MYSM1 (Myb-Like, SWIRM and MPN Domains 1 (MYSM1))

Alternative Name: Myb like, SWIRM and MPN domains 1

Background: Myb like, SWIRM and MPN domains 1 , 2A-DUB , 2ADUB , BMFS4,Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.

Molecular Weight: 95 kDa

Gene ID: 114803

UniProt: Q5VVJ2

Pathways: Chromatin Binding