GRAF antibody (C-Term)

Catalog No. ABIN7466095

The Rabbit Polyclonal anti-GRAF antibody has been validated for WB. It is suitable to detect GRAF in samples from Human.

Quick Overview for GRAF antibody (C-Term) (ABIN7466095)

Target: GRAF (ARHGAP26) (rho GTPase Activating Protein 26 (ARHGAP26))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRAF antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GRAF Antibody

Binding Specificity: C-Term

Cross-Reactivity: Human

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human GRAF. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: HepG2

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for GRAF

Target: GRAF (ARHGAP26) (rho GTPase Activating Protein 26 (ARHGAP26))

Alternative Name: Rho GTPase activating protein 26

Background: Rho GTPase activating protein 26 , GRAF , GRAF1 , OPHN1L , OPHN1L1,Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Molecular Weight: 92 kDa

Gene ID: 23092

UniProt: Q9UNA1