XPO1 antibody (N-Term)

Catalog No. ABIN7466573

This anti-XPO1 antibody is a Rabbit Polyclonal antibody detecting XPO1 in WB and IHC (p). Suitable for Human.

Quick Overview for XPO1 antibody (N-Term) (ABIN7466573)

Target: XPO1 (Exportin 1 (XPO1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This XPO1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: KO Validated

Product Details anti-XPO1 Antibody

Binding Specificity: N-Term

Cross-Reactivity: Human, Mouse

Purification: Affinity purified by Protein A.

Immunogen: Recombinant protein encompassing a sequence within the N-terminus region of human CRM1. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Validation: KO/KD

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.54 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for XPO1

Target: XPO1 (Exportin 1 (XPO1))

Alternative Name: exportin 1

Background: Exportin 1 , CRM1 , emb , exp1,This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jan 2015]

Molecular Weight: 123 kDa

Gene ID: 7514

UniProt: O14980

Pathways: M Phase