Sec8 antibody

Catalog No. ABIN7467783

This Rabbit Polyclonal antibody specifically detects Sec8 in IF, ICC and IHC (p). It exhibits reactivity toward Human.

Quick Overview for Sec8 antibody (ABIN7467783)

Target: Sec8 (EXOC4) (Exocyst Complex Component 4 (EXOC4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Sec8 antibody is un-conjugated

Application: Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Sec8 Antibody

Cross-Reactivity: Human

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human Sec8. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for Sec8

Target: Sec8 (EXOC4) (Exocyst Complex Component 4 (EXOC4))

Alternative Name: exocyst complex component 4

Background: Exocyst complex component 4 , SEC8 , SEC8L1 , Sec8p,The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]

Molecular Weight: 110 kDa

Gene ID: 60412

UniProt: Q96A65

Pathways: Peptide Hormone Metabolism, Synaptic Vesicle Exocytosis