CYFIP1 antibody (C-Term)

Catalog No. ABIN7467857

This anti-CYFIP1 antibody is a Rabbit Polyclonal antibody detecting CYFIP1 in IHC (p). Suitable for Human.

Quick Overview for CYFIP1 antibody (C-Term) (ABIN7467857)

Target: CYFIP1 (Cytoplasmic FMR1 Interacting Protein 1 (CYFIP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYFIP1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-CYFIP1 Antibody

Binding Specificity: C-Term

Cross-Reactivity: Mouse

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human CYFIP1. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for CYFIP1

Target: CYFIP1 (Cytoplasmic FMR1 Interacting Protein 1 (CYFIP1))

Alternative Name: cytoplasmic FMR1 interacting protein 1

Background: Cytoplasmic FMR1 interacting protein 1 , P140SRA-1 , SHYC , SRA-1 , SRA1,Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Involved in formation of membrane ruffles and lamellipodia protrusions and in axon outgrowth. Binds to F-actin but not to RNA. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers.

Molecular Weight: 145 kDa

Gene ID: 23191

UniProt: Q7L576