E3 Ubiquitin-Protein Ligase CBL-C (CBLC) antibody

Catalog No. ABIN7468288

The Rabbit Polyclonal anti-E3 Ubiquitin-Protein Ligase CBL-C antibody is suitable to detect E3 Ubiquitin-Protein Ligase CBL-C in samples from Human. It has been validated for WB.

Quick Overview for E3 Ubiquitin-Protein Ligase CBL-C (CBLC) antibody (ABIN7468288)

Target: E3 Ubiquitin-Protein Ligase CBL-C (CBLC)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Product Details

Cross-Reactivity: Mouse

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human CBLC. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: mouse kidney

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.8 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details

Target: E3 Ubiquitin-Protein Ligase CBL-C (CBLC)

Alternative Name: Cbl proto-oncogene C

Background:

Synonyms: Cbl proto-oncogene C , CBL-3 , CBL-SL , RNF57

Background: CBL proteins, such as CBLC, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC (MIM 190090) homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling (Keane et al., 1999 [PubMed 10362357]).[supplied by OMIM]

Molecular Weight: 52 kDa

Gene ID: 23624

UniProt: Q9ULV8