ER Degradation-Enhancing alpha-Mannosidase-Like Protein 1 (EDEM1) (C-Term) antibody

Catalog No. ABIN7468312

The Rabbit Polyclonal anti-ER Degradation-Enhancing alpha-Mannosidase-Like Protein 1 antibody is suitable to detect ER Degradation-Enhancing alpha-Mannosidase-Like Protein 1 in samples from Human. It has been validated for WB.

Quick Overview for ER Degradation-Enhancing alpha-Mannosidase-Like Protein 1 (EDEM1) (C-Term) antibody (ABIN7468312)

Target: ER Degradation-Enhancing alpha-Mannosidase-Like Protein 1 (EDEM1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Application: Western Blotting (WB)

Product Details

Binding Specificity: C-Term

Cross-Reactivity: Human

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human EDEM1. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: Jurkat membrane extract Validation: Orthogonal

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.21 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details

Target: ER Degradation-Enhancing alpha-Mannosidase-Like Protein 1 (EDEM1)

Alternative Name: ER degradation enhancing alpha-mannosidase like protein 1

Background:

Synonyms: ER degradation enhancing alpha-mannosidase like protein 1 , EDEM

Background: Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It lacks mannosidase activity.

Molecular Weight: 74 kDa

Gene ID: 9695

UniProt: Q92611