GREM2 antibody (C-Term)

Catalog No. ABIN7468386

This Rabbit Polyclonal antibody specifically detects GREM2 in WB, ICC, IHC (p) and IF. It exhibits reactivity toward Human.

Quick Overview for GREM2 antibody (C-Term) (ABIN7468386)

Target: GREM2 (Gremlin 2 (GREM2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GREM2 antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Product Details anti-GREM2 Antibody

Binding Specificity: C-Term

Cross-Reactivity: Human, Rat

Purification: Purified by antigen-affinity chromatography.

Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human GREM2. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Validation: Overexpression

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.26 mg/mL

Buffer: 1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for GREM2

Target: GREM2 (Gremlin 2 (GREM2))

Alternative Name: gremlin 2, DAN family BMP antagonist

Background:

Synonyms: gremlin 2, DAN family BMP antagonist , CKTSF1B2 , DAND3 , PRDC , STHAG9

Background: This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. [provided by RefSeq]

Molecular Weight: 19 kDa

Gene ID: 64388

UniProt: Q9H772