LILRB3 antibody

Catalog No. ABIN7468542

This Rabbit Polyclonal antibody specifically detects LILRB3 in WB. It exhibits reactivity toward Human.

Quick Overview for LILRB3 antibody (ABIN7468542)

Target: LILRB3 (Leukocyte Immunoglobulin-Like Receptor B3 (LILRB3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LILRB3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-LILRB3 Antibody

Cross-Reactivity: Human

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human LILRB3. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: Jurkat

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for LILRB3

Target: LILRB3 (Leukocyte Immunoglobulin-Like Receptor B3 (LILRB3))

Alternative Name: leukocyte immunoglobulin like receptor B3

Background:

Synonyms: leukocyte immunoglobulin like receptor B3 , CD85A , HL9 , ILT-5 , ILT5 , LILRA6 , LIR-3 , LIR3 , PIR-B , PIRB

Background: This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Molecular Weight: 69 kDa

Gene ID: 11025