PMS2CL/PMS2 antibody (N-Term)

Catalog No. ABIN7468755

This Rabbit Polyclonal antibody specifically detects PMS2CL/PMS2 in IP and WB. It exhibits reactivity toward Human.

Quick Overview for PMS2CL/PMS2 antibody (N-Term) (ABIN7468755)

Target: PMS2CL/PMS2 (PMS2) (PMS1 Homolog 2, Mismatch Repair System Component (PMS2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PMS2CL/PMS2 antibody is un-conjugated

Application: Immunoprecipitation (IP), Western Blotting (WB)

Product Details anti-PMS2CL/PMS2 Antibody

Binding Specificity: N-Term

Cross-Reactivity: Human

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the N-terminus region of human PMS2. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:10000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: human PMS2-transfected 293T cells , A431 , HeLa , HepG2 Validation: Overexpression

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for PMS2CL/PMS2

Target: PMS2CL/PMS2 (PMS2) (PMS1 Homolog 2, Mismatch Repair System Component (PMS2))

Alternative Name: PMS1 homolog 2, mismatch repair system component

Background:

Synonyms: PMS1 homolog 2, mismatch repair system component , HNPCC4 , MLH4 , PMS2CL , PMSL2

Background: This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq]

Molecular Weight: 96 kDa

Gene ID: 5395

UniProt: P54278