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TIMELESS antibody (C-Term)

The Rabbit Polyclonal anti-TIMELESS antibody has been validated for WB, IP, IF and ICC. It is suitable to detect TIMELESS in samples from Human.
Catalog No. ABIN7469068

Quick Overview for TIMELESS antibody (C-Term) (ABIN7469068)

Target

See all TIMELESS Antibodies
TIMELESS (Timeless Homolog (TIMELESS))

Reactivity

  • 33
  • 15
  • 12
  • 9
  • 7
  • 6
  • 5
  • 5
  • 4
  • 4
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Host

  • 33
  • 3
  • 1
Rabbit

Clonality

  • 34
  • 3
Polyclonal

Conjugate

  • 30
  • 4
  • 2
  • 1
This TIMELESS antibody is un-conjugated

Application

  • 29
  • 15
  • 10
  • 8
  • 6
  • 4
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC)
  • Binding Specificity

    • 8
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    C-Term

    Cross-Reactivity

    Human, Mouse

    Purification

    Purified by antigen-affinity chromatography.

    Immunogen

    Recombinant protein encompassing a sequence within the C-terminus region of human TIMELESS. The exact sequence is proprietary.

    Isotype

    IgG
  • Application Notes

    WB: 1:500-1:3000. ICC/IF: 1:100-1:2000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

    Comment

    Positive Control: 293T , A431 , HeLa , HepG2 , Neuro2A , C8D30 , NIH-3T3 , Raw 264.7 , C2Cl2

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 mg/mL

    Buffer

    1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300

    Preservative

    ProClin

    Precaution of Use

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    4 °C,-20 °C

    Storage Comment

    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target

    TIMELESS (Timeless Homolog (TIMELESS))

    Alternative Name

    timeless circadian regulator

    Background

    Synonyms: timeless circadian regulator , TIM , TIM1 , hTIM

    Background: Required for normal progression of S-phase. Involved in the circadian rhythm autoregulatory loop. Negatively regulates CLOCK-NPAS2/BMAL1-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Promotes TIPIN nuclear localiZation. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules.

    Molecular Weight

    139 kDa

    Gene ID

    8914

    UniProt

    Q9UNS1

    Pathways

    Protein targeting to Nucleus, Photoperiodism
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