GATSL3 antibody
Quick Overview for GATSL3 antibody (ABIN7469300)
Target
Reactivity
Host
Clonality
Conjugate
Application
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Cross-Reactivity
- Human
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Purification
- Purified by antigen-affinity chromatography.
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Immunogen
- Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human GATSL3. The exact sequence is proprietary.
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Isotype
- IgG
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anti-GATS Protein-Like 3 (GATSL3) (C-Term) antibody
GATSL3 Reactivity: Human, Cow, Dog, Guinea Pig, Horse, Mouse, Rabbit, Rat WB Host: Rabbit Polyclonal unconjugated
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Application Notes
- WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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Comment
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Positive Control: MCF-7 , MDA-MB-231
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1.9 mg/mL
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Buffer
- 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300
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Preservative
- ProClin
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Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- 4 °C,-20 °C
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Storage Comment
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- GATSL3 (GATS Protein-Like 3 (GATSL3))
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Alternative Name
- GATSL3
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Background
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Synonyms: cytosolic arginine sensor for mTORC1 subunit 1 , GATSL3
Background: Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.
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Molecular Weight
- 36 kDa
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Gene ID
- 652968
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UniProt
- Q8WTX7
Target
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