SENP8 antibody (N-Term)

Catalog No. ABIN7469621

The Rabbit Polyclonal anti-SENP8 antibody (ABIN7469621) specifically detects SENP8 in WB and IHC (p). The antibody is reactive with Human samples.

Quick Overview for SENP8 antibody (N-Term) (ABIN7469621)

Target: SENP8 (SUMO/sentrin Specific Peptidase Family Member 8 (SENP8))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SENP8 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-SENP8 Antibody

Binding Specificity: N-Term

Cross-Reactivity: Human

Purification: Purified by antigen-affinity chromatography.

Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human SENP8. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: Raji

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for SENP8

Target: SENP8 (SUMO/sentrin Specific Peptidase Family Member 8 (SENP8))

Alternative Name: SENP8

Background:

Synonyms: SUMO peptidase family member, NEDD8 specific , DEN1 , NEDP1 , PRSC2

Background: NEDD8 (MIM 603171) is a ubiquitin-like protein that becomes conjugated to the cullin (see CUL1, MIM 603134) subunit of several ubiquitin ligases. This conjugation, called neddylation, is required for optimal ubiquitin ligase activity. NEDD8-specific deneddylases, such as NEDP1, or DEN1, are required to process the NEDD8 propeptide at a C-terminal diglycine motif and to remove NEDD8 from cullins (Gan-Erdene et al., 2003 [PubMed 12759363]).[supplied by OMIM]

Molecular Weight: 24 kDa

Gene ID: 123228

UniProt: Q96LD8