Cytohesin 1 antibody (AA 321-398)

Catalog No. ABIN720251

The Rabbit Polyclonal anti-Cytohesin 1 antibody has been validated for WB, ELISA, IHC (p), IF (cc), IF (p) and IHC (fro). It is suitable to detect Cytohesin 1 in samples from Human.

Quick Overview for Cytohesin 1 antibody (AA 321-398) (ABIN720251)

Target: Cytohesin 1 (CYTH1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cytohesin 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-Cytohesin 1 Antibody

Binding Specificity: AA 321-398

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PSCD1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for Cytohesin 1

Target: Cytohesin 1 (CYTH1)

Alternative Name: PSCD1

Background:

Synonyms: SEC7 and coiled-coil domain-containing protein 1, B2 1, CLM1, CTH 1, CYH1_HUMAN, CYTH1, CYTIP, Cytoadhesin 1, Cytohesin-1, Homolog of secretory protein SEC7, mSec7 1, PH, PH, SEC7 and coiled-coil domain containing protein 1, Pleckstrin homology Sec7 and coiled/coil domains 1, Pleckstrin homology Sec7 and coiled/coil domains protein 1, PSCD1, Sec7, SEC7 homolog A, SEC7 homolog B2 1, SEC7 homolog B2-1, SEC7, yeast, homolog of, Sec7a.

Background: Cytohesin 1 is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. Cytohesin 1 is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. The encoded protein is 83 % homologous to that of CYTH2.

Gene ID: 9267