Recombinant IL-7 antibody

Catalog No. ABIN7482272

The Mouse Monoclonal anti-IL-7 antibody has been validated for ELISA. It is suitable to detect IL-7 in samples from Mouse.

Quick Overview for Recombinant IL-7 antibody (ABIN7482272)

Target: IL-7 (IL7) (Interleukin 7 (IL7))

Antibody Type: Recombinant Antibody

Reactivity: Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL-7 antibody is un-conjugated

Application: ELISA

Clone: 4C9F12

Product Details anti-IL-7 Antibody

Purpose: Mouse IL-7 Antibody, Mouse IgG1 (4C9F12)

Immunogen: Mouse IL-7 Antibody, Mouse IgG1 (4C9F12) is a chimeric monoclonal antibody recombinantly expressed from human 293 cells (HEK293), which combines the variable region of a mouse monoclonal antibody with mouse IgG1 constant domain. The mouse monoclonal antibody is produced from a hybridoma resulting from fusion of SP2/0 myeloma and B-lymphocytes obtained from a mouse immunized with IL-7.

Isotype: IgG1

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Storage: -20 °C

Target Details for IL-7

Target: IL-7 (IL7) (Interleukin 7 (IL7))

Alternative Name: IL-7

Background: Interleukin 7 is also known as IL7, IL-7, and is a hematopoietic growth factor secreted by stromal cells in the red marrow and thymus. It is also produced by keratinocytes, dendritic cells, hepatocytes, neurons, and epithelial cells, but is not produced by lymphocytes. IL-7 stimulates the differentiation of multipotent (pluripotent) hematopoietic stem cells into lymphoid progenitor cells, It also stimulates proliferation of all cells in the lymphoid lineage (B cells, T cells and NK cells). It is important for proliferation during certain stages of B-cell maturation, T and NK cell survival, development and homeostasis. IL-7 is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. IL-7 binds to the IL-7 receptor, a heterodimer consisting of Interleukin-7 receptor alpha and common gamma chain receptor. Il-7 promotes hematological malignacies (acute lymphoblastic leukemia, T cell lymphoma). Elevated levels of IL-7 have also been detected in the plasma of HIV-infected patients. IL-7 as an immunotherapy agent has been examined in many pre-clinical animal studies and more recently in human clinical trials for various malignancies and during HIV infection. IL-7 could also be beneficial in improving immune recovery after allogenic stem cell transplant.

Pathways: JAK-STAT Signaling