LRRC4C antibody (AA 561-640) (Cy3)

Catalog No. ABIN720299

The Rabbit Polyclonal anti-LRRC4C antibody has been validated for WB, IF (cc) and IF (p). It is suitable to detect LRRC4C in samples from Human, Mouse and Rat.

Quick Overview for LRRC4C antibody (AA 561-640) (Cy3) (ABIN720299)

Target: LRRC4C (Leucine Rich Repeat Containing 4C (LRRC4C))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRRC4C antibody is conjugated to Cy3

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-LRRC4C Antibody (Cy3)

Binding Specificity: AA 561-640

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Netrin G1 ligand

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for LRRC4C

Target: LRRC4C (Leucine Rich Repeat Containing 4C (LRRC4C))

Alternative Name: Netrin G1 ligand

Background:

Synonyms: Leucine rich repeat containing 4C, Leucine-rich repeat-containing protein 4C, LRC4C_HUMAN, Lrrc4C, Netrin-G1 ligand, NGL 1, NGL-1, NGL1.

Background: NGL-1 is a single pass type I membrane protein that acts as a cell adhesion molecule. It contains nine leucine-rich repeats (LRR) and one Ig-like C2-type domain. NGL-1 is predominantly expressed in the striatum and the cerebral cortex of both the embryonic and adult brain. NGL-1 specifically interacts with Netrin G1 (a molecule involved in axon guidance in the developing central nervous system) via its LRR region. NGL-1 plays a role in the regulation of neurite outgrowth of developing thalamic neurons. Soluble NGL-1 inhibits thalamic axon outgrowth while NGL-1 that is bound to the surface of developing thalamocortical axons stimulates growth. NGL-1 also interacts with Whirlin possibly stablizing interstereociliar links.

Gene ID: 22854

Pathways: Synaptic Membrane