Recombinant CEA antibody

Catalog No. ABIN7487714

This Rabbit Chimeric antibody specifically detects CEA in ISG. It exhibits reactivity toward Human.

Quick Overview for Recombinant CEA antibody (ABIN7487714)

Target: CEA (Carcinoembryonic Antigen Gene Family (CEA))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Chimeric

Conjugate: This CEA antibody is un-conjugated

Application: Immunoscintigraphy (ISG)

Clone: BW431-26

Product Details anti-CEA Antibody

Purpose: Anti-CEA [BW431/26], Rabbit IgG, kappa

Specificity: This antibody recognizes and binds human carcinoembryonic antigen in its purified state as well as on tissue sections.

Characteristics:

Original Species of Ab: Mouse

Original Format of Ab: IgG3

Purification: Protein A affinity purified

Immunogen: The original antibody was generated by immunizing mice with CEA positive adenocarcinoma cells preferably from lungs.

Isotype: IgG kappa

Application Details

Application Notes: Technetium 99-labeled (Tc-99m) BW431/26 has been used in the diagnosis and detection of colorectal carcinomas, breast cancers, bladder carcinomas, lung adenocarcinomas and their recurrences by immunoscintigraphy (PMID: 2602902, 2662074, 2685692, 2297747, 2157833, 2166552, 2383485, 1984945 ). The use of Tc-99m-BW 431/26 immunoconjugates in immunoscintigraphy resulted in reduction of radiation dose for the patient down to 5 % of the dose applied as compared with I-131 labelled MAbs (PMID: 3262953). Humanized version of this antibody also shows similar binding affinity as compared to its murine parent antibody (PMID: 1762576).

Comment:

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG3 format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for CEA

Target: CEA (Carcinoembryonic Antigen Gene Family (CEA))

Alternative Name: CEA

Background: Carcinoembryonic antigen, Carcinoembryonic antigen-related cell adhesion molecule 5, CEACAM5, Meconium antigen 100, CD66e

UniProt: P06731