Integrin beta 3 antibody (PE)

Catalog No. ABIN7489343

The Mouse Monoclonal anti-Integrin beta 3 antibody has been validated for FACS. It is suitable to detect Integrin beta 3 in samples from Human.

Quick Overview for Integrin beta 3 antibody (PE) (ABIN7489343)

Target: Integrin beta 3 (ITGB3)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Integrin beta 3 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Grade: GMP Grade

Clone: C-61-13

Product Details anti-Integrin beta 3 Antibody (PE)

Purpose: CD61 PE Antibody

Characteristics: The clone C-61.13, a mouse monoclonal antibody, specifically binds to the 90-110 kDa integral cell-surface protein known as CD61 or Integrin beta-3 (β3) that in humans is encoded by the ITGB3 gene. CD61 is expressed on the surface of platelets and megakaryocytes. CD61 (platelet glycoproteins IIIa) and CD41 (platelet glycoprotein IIb) form a calcium-dependent heterodimeric complex. This glycoprotein complex (GPIIb-IIIa) binds plasma proteins, such as fibrinogen, fibronectin, von Willebrand factor, and vitronectin, and plays a critical role in platelet aggregation.

Purification: Purified

Purity: >95 %

Immunogen: Recombinant human ITGB3 protein

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS pH 7.2, 0.2 % (w/v) BSA, 0.09 % (w/v) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: 2-8°C, Conjugated antibodies should never be frozen.

Target Details for Integrin beta 3

Target: Integrin beta 3 (ITGB3)

Alternative Name: CD61

Gene ID: 933

NCBI Accession: NM_001771

UniProt: P20273

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Integrin Complex