Prostaglandin D2 Receptor 2 (PTGDR2) antibody

Catalog No. ABIN7505893

The Rat Monoclonal anti-Prostaglandin D2 Receptor 2 antibody is suitable to detect Prostaglandin D2 Receptor 2 in samples from Human. It has been validated for FACS.

Quick Overview for Prostaglandin D2 Receptor 2 (PTGDR2) antibody (ABIN7505893)

Target: Prostaglandin D2 Receptor 2 (PTGDR2)

Reactivity: Human

Host: Rat

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Flow Cytometry (FACS)

Clone: BM16

Product Details

Purpose: Anti-Hu CD294 Purified

Characteristics: The rat monoclonal antibody BM16 recognizes an extracellular epitope of CD294 / CRTH2 (prostaglandin D2 receptor 2), a G-protein-coupled seven-transmembrane protein expressed on Th2 cells, peripheral blood basophils and eosinophils.

Purification: Purified by protein-G affinity chromatography.

Immunogen: Human CD294 transfected rat cell line TART/B19-12.10

Isotype: IgG2a

Application Details

Application Notes: Flow cytometry: Recommended dilution: 1-4 μg/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

Target Details

Target: Prostaglandin D2 Receptor 2 (PTGDR2)

Alternative Name: CD294

Background: Prostaglandin D2 receptor 2,CD294 (prostaglandin D2 receptor 2) is a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells, but also on eosinophils and basophils. It mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of CD294 gene have been associated with asthma susceptibility. Outside the immune system CD294 is expressed e.g. in gut, heart, and brain. The intracellular C terminal tail contains sites for phosphorylation by protein kinase C.,DP2, PTGDR2, DL1R, CRTH2, GPR44

Gene ID: 11251

UniProt: Q9Y5Y4

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling