TIAL1 antibody
Quick Overview for TIAL1 antibody (ABIN7506023)
Target
See all TIAL1 AntibodiesReactivity
Host
Clonality
Conjugate
Application
Clone
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Purpose
- Anti-TIAR Purified
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Specificity
- The mouse monoclonal antibody 6E3 recognizes TIAR, an ubiquitously expressed approximately 42 kDa intracellular RNA-binding protein.
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Purification
- Purified by protein-A affinity chromatography.
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Immunogen
- GST-tagged recombinant human TIAR
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Isotype
- IgG2a kappa
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anti-TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1) (AA 266-375) antibody
TIAL1 Reactivity: Human WB, IHC Host: Rabbit Polyclonal unconjugated
anti-TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1) antibodyTIAL1 Reactivity: Human, Mouse, Rat WB, IHC Host: Rabbit Polyclonal unconjugated
anti-TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1) (AA 1-252) antibodyTIAL1 Reactivity: Human WB, IF Host: Mouse Polyclonal unconjugated
anti-TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1) (Internal Region) antibodyTIAL1 Reactivity: Human, Mouse, Rat WB, ELISA Host: Rabbit Polyclonal unconjugated
anti-TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1) (AA 1-90) antibodyTIAL1 Reactivity: Human WB, ELISA Host: Mouse Polyclonal unconjugated
anti-TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1) (Internal Region) antibodyVerified TIAL1 Reactivity: Human WB, ELISA, IHC Host: Goat Polyclonal unconjugated
anti-TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1) (AA 9-277) antibodyTIAL1 Reactivity: Human ELISA, IF Host: Rabbit Polyclonal unconjugated
anti-TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1) (C-Term) antibodyTIAL1 Reactivity: Human, Mouse, Rat, Dog, Rabbit, Zebrafish (Danio rerio), Cow, Guinea Pig, Horse, Chicken, Bat, Pig, Monkey WB Host: Rabbit Polyclonal unconjugated
anti-TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1) (AA 275-325) antibodyTIAL1 Reactivity: Human, Mouse IHC, IP, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1) (C-Term) antibodyTIAL1 Reactivity: Human, Mouse, Rat, Dog, Zebrafish (Danio rerio), Chicken, Xenopus laevis WB Host: Rabbit Polyclonal unconjugated
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Application Notes
- Flow cytometry: Intracellular staining, recommended dilution: 5 μg/mL
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Restrictions
- For Research Use only
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Concentration
- 1 mg/mL
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Buffer
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- 4 °C
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Storage Comment
- Store at 2-8°C. Do not freeze.
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- TIAL1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1))
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Alternative Name
- TIAR
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Background
- TIA1 cytotoxic granule associated RNA binding prot,TIAR is an ubiquitously expressed RNA-binding protein, which regulates translational control, splicing, and other activities, including apoptosis. TIAR attenuates CDK1 activity, and is essential for the G2/M checkpoint. It accumulates in nuclear foci in late G2 phase and prophase in cells under replication stress. In steady state TIAR shuttles between the cytoplasm and the nucleus, probably as a part of nucleocytoplasmic transport of mRNA, but under stress conditions it accumulates mRNA molecules in granules and prevents their translation. Nucleolytic activity of TIAR against attacked target cells of cytotoxic lymphocytes has also been reported. Similarly, e.g. in permeabilized thymocytes TIAR triggers DNA fragmentation.,TCBP, TIAL1
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Gene ID
- 7073
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UniProt
- Q01085
Target
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