CCR4 antibody (PE)

Catalog No. ABIN7536961

This anti-CCR4 antibody is a Mouse Monoclonal antibody detecting CCR4 in FACS. Suitable for Human.

Quick Overview for CCR4 antibody (PE) (ABIN7536961)

Target: CCR4 (Chemokine (C-C Motif) Receptor 4 (CCR4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CCR4 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Clone: L291H4

Product Details anti-CCR4 Antibody (PE)

Purpose: PE Anti-Human CD194/CCR4 Antibody [L291H4]

Purification: Purified

Isotype: IgG1, kappa

Application Details

Application Notes: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. The amount of the reagent is suggested to be used 5 μL of antibody per test (million cells in 100 μL staining volume or per 100 μL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.

Comment:

Matching Isotype Control: (ABIN7469761)

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered solution, pH 7.2, containing 0.09 % stabilizer and 1 % protein protectant.

Storage: 4 °C

Storage Comment: This product can be stored at 2-8°C for 12 months. Do not freeze.

Expiry Date: 12 months

Target Details for CCR4

Target: CCR4 (Chemokine (C-C Motif) Receptor 4 (CCR4))

Alternative Name: CD194/CCR4

Background: CD194/CCR4,CKR4,K5-5,CMKBR4,ChemR13,CC-CKR-4,MGC88293,HGCN:14099,CD194, also known as CCR4, is a CC chemokine receptor. It binds CCL17 and CCL22 and is expressed on a subset of T and B cells, basophils, monocytes, and NK cells. Human Th2 cells are characterized by the expression of CCR4 and CCR8, and these receptors are regulated differently during Th2 development. Human peripheral blood Tregs can be divided into two distinct populations based on the expression of CCR4. Freshly isolated Tregs express CCR4 and presumably represent memory-type Tregs, and CCR4-?Tregs require CD3-mediated activation to acquire a regulatory activity. Depletion of CCR4+?T cells leads to Th1-type polarization of CD4+?T cells and augmentation of CD8+?T cell responses to tumor antigens. CCR4 and its ligands are important for the recruitment of memory T cells into the skin in various cutaneous immune diseases.

UniProt: P51679