FOXP3 antibody (PE)

Catalog No. ABIN7537019

This Rat Monoclonal antibody specifically detects FOXP3 in ICFC. It exhibits reactivity toward Mouse.

Quick Overview for FOXP3 antibody (PE) (ABIN7537019)

Target: FOXP3 (Forkhead Box P3 (FOXP3))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This FOXP3 antibody is conjugated to PE

Application: Intracellular Flow Cytometry (ICFC)

Clone: FJK-16s

Product Details anti-FOXP3 Antibody (PE)

Purpose: PE Anti-Mouse/Rat Foxp3 Antibody [FJK-16s]

Purification: Purified

Isotype: IgG2a, kappa

Application Details

Application Notes: Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/10⁶ cells in 100 μL volume].

Comment:

Matching Isotype Control: (ABIN7469840)

Restrictions: For Research Use only

Handling

Concentration: 0.2 mg/mL

Buffer: Phosphate buffered solution, pH 7.2, containing 0.09 % stabilizer and 1 % protein protectant.

Storage: 4 °C

Storage Comment: This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Expiry Date: 12 months

Target Details for FOXP3

Target: FOXP3 (Forkhead Box P3 (FOXP3))

Alternative Name: Foxp3

Background: Foxp3,Forkhead box protein P3, Scurfin, JM2, IPEX, Zinc finger protein JM2,FOXP3 is a 47 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4⁺/CD25^- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in "scurfy" mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity.

Gene ID: 20371

UniProt: Q99JB6

Pathways: Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation