TRAIL antibody

Catalog No. ABIN7539279

This Rabbit Polyclonal antibody specifically detects TRAIL in WB. It exhibits reactivity toward Human.

Quick Overview for TRAIL antibody (ABIN7539279)

Target: TRAIL (TNFSF10) (Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRAIL antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TRAIL Antibody

Purpose: TRAIL/Apo2L antibody

Specificity: Chromosomal location:3q26

Purification: Protein-A purified

Immunogen: recombinant human TRAIL/ApoL2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.

Buffer: PBS

Storage: 4 °C,-20 °C

Storage Comment: The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.

Expiry Date: 24 months

Target Details for TRAIL

Target: TRAIL (TNFSF10) (Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))

Alternative Name: TRAIL/Apo2L

Background: TNFSF10, TL2, APO2L, CD253, TRAIL, Apo-2L,TNF-related apoptosis-inducing ligand (TRAIL) is a ligand molecule which induces apoptosis. It is a type II transmembrane protein with homology to other members of the tumor necrosis factor family. In humans, the gene that encodes for TRAIL is located at chromosome 3q26. TRAIL binds to the death receptors, DR4 and DR5. The process of apoptosis is caspase-8-dependent. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues.

Gene ID: 8743

NCBI Accession: NM_003810, NP_003801

UniProt: P50591

Pathways: Apoptosis, Positive Regulation of Endopeptidase Activity