VEGFC antibody (Biotin)

Catalog No. ABIN7539286

The Rabbit Polyclonal anti-VEGFC antibody has been validated for ELISA. It is suitable to detect VEGFC in samples from Rat.

Quick Overview for VEGFC antibody (Biotin) (ABIN7539286)

Target: VEGFC (Vascular Endothelial Growth Factor C (VEGFC))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VEGFC antibody is conjugated to Biotin

Application: ELISA

Product Details anti-VEGFC Antibody (Biotin)

Purpose: VEGF-C antibody

Specificity: Chromosomal location:16p11

Purification: Antigen-affinity purified

Immunogen: Recombinant rat VEGF-C (RT #R20-015)

Application Details

Application Notes: ELISA: Use 1-10 μg/mL

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.

Buffer: PBS, BSA (50x), 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.

Expiry Date: 24 months

Target Details for VEGFC

Target: VEGFC (Vascular Endothelial Growth Factor C (VEGFC))

Alternative Name: VEGF-C

Background: Vascular endothelial growth factor C, Vegfc,VEGF-C, a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. It promotes endothelial cell growth, promotes lymphangiogesis, and can also affect vascular permeability. VEGF-C is expressed in various tissues, but is not produced in peripheral blood lymphocytes. It forms cell surfaced-associated non-covalent disulfide linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors. During embryogenesis, VEGF-C may play a role in the formation of the venous and lymphatic vascular systems. Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis. Recombinant, fully processed rat VEGF-C is a 16-18 kDa non-disulfide linked homodimeric protein consisting of two 116 amino acid polypeptide chains. Due to glycosylation the protein migrates as a 20.0-22.0 kDa band under non-reducing condition.

Gene ID: 114111

NCBI Accession: NM_053653, NP_446105

UniProt: O35757

Pathways: RTK Signaling, Signaling Events mediated by VEGFR1 and VEGFR2