PKD1 antibody (AA 3682-3873)

Catalog No. ABIN7539645

This Rat Monoclonal antibody specifically detects PKD1 in ELISA and FACS. It exhibits reactivity toward Human.

Quick Overview for PKD1 antibody (AA 3682-3873) (ABIN7539645)

Target: PKD1 (Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1))

Reactivity: Human

Host: Rat

Clonality: Monoclonal

Conjugate: This PKD1 antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS)

Clone: 8C3D11

Product Details anti-PKD1 Antibody

Binding Specificity: AA 3682-3873

Purpose: PKD1 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of mouse PKD1 (AA: 3682-3873) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for PKD1

Target: PKD1 (Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1))

Alternative Name: PKD1

Background: Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Acts as a regulator of cilium length, together with PKD2. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate.

Molecular Weight: 466 kDa

Gene ID: 18763

UniProt: O08852

Pathways: Myometrial Relaxation and Contraction, Maintenance of Protein Location