PKD1 antibody (AA 131-230)

Catalog No. ABIN678083

There are 4+ publications for this product available. The Rabbit Polyclonal anti-PKD1 antibody is suitable to detect PKD1 in samples from Human. It has been validated for WB, FACS, IF (cc), IF (p), IHC (p) and IHC (fro).

Quick Overview for PKD1 antibody (AA 131-230) (ABIN678083)

Target: PKD1 (Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PKD1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-PKD1 Antibody

Binding Specificity: AA 131-230

Purpose: Polycystin 1 Polyclonal Antibody

Cross-Reactivity: Human

Predicted Reactivity: Mouse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Polycystin 1

Isotype: IgG

Application Details

Application Notes: WB(1:300-5000),

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-PKD1 antibody (ABIN678083)

Ren, Xia, Yang, Zhu, Zhang, Chen, Zhao, Sun, Zhao: "Down-regulation of polycystin in lymphatic malformations: possible role in the proliferation of lymphatic endothelial cells." in: Human pathology, Vol. 65, pp. 231-238, (2017) (PubMed).

Kito, Saigo, Takeuchi: "Novel Transgenic Mouse Model of Polycystic Kidney Disease." in: The American journal of pathology, Vol. 187, Issue 9, pp. 1916-1922, (2017) (PubMed).

Ohata, Herranz-Pérez, Nakatani, Boletta, García-Verdugo, Álvarez-Buylla: "Mechanosensory Genes Pkd1 and Pkd2 Contribute to the Planar Polarization of Brain Ventricular Epithelium." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 31, pp. 11153-68, (2015) (PubMed).

Chiou, Sang, Cheng, Ho, Wang, Pan: "Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently prevents skin carcinogenesis by suppressing the PKD1-dependent signaling pathway in CD34+ skin stem cells and skin tumors." in: Carcinogenesis, Vol. 34, Issue 6, pp. 1315-22, (2013) (PubMed).

Target Details for PKD1

Target: PKD1 (Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1))

Alternative Name: Polycystin 1

Background:

Synonyms: PBP, Pc-1, TRPP1, Polycystin-1, Autosomal dominant polycystic kidney disease 1 protein, PKD1

Background: Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Acts as a regulator of cilium length, together with PKD2. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity). May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions.

Gene ID: 5310

UniProt: P98161

Pathways: Myometrial Relaxation and Contraction, Maintenance of Protein Location