TCF7 antibody (AA 168-358)

Catalog No. ABIN7539769

The Mouse Monoclonal anti-TCF7 antibody is suitable to detect TCF7 in samples from Human. It has been validated for ELISA, IHC, ICC and FACS.

Quick Overview for TCF7 antibody (AA 168-358) (ABIN7539769)

Target: TCF7 (Transcription Factor 7 (T-Cell Specific, HMG-Box) (TCF7))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TCF7 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Clone: 1B4E9

Product Details anti-TCF7 Antibody

Binding Specificity: AA 168-358

Purpose: TCF7 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human TCF7 (AA: 168-358) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for TCF7

Target: TCF7 (Transcription Factor 7 (T-Cell Specific, HMG-Box) (TCF7))

Alternative Name: TCF7

Background: This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation. Alternative splicing results in multiple transcript variants. Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling.

Molecular Weight: 41.6 kDa

Gene ID: 6932

UniProt: P36402

Pathways: WNT Signaling