C9ORF72 antibody (AA 110-199)

Catalog No. ABIN7539802

The Mouse Monoclonal anti-C9ORF72 antibody has been validated for ELISA, IHC and FACS. It is suitable to detect C9ORF72 in samples from Human and Rat.

Quick Overview for C9ORF72 antibody (AA 110-199) (ABIN7539802)

Target: C9ORF72 (Chromosome 9 Open Reading Frame 72 (C9ORF72))

Reactivity: Human, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This C9ORF72 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Clone: 4D5G1

Product Details anti-C9ORF72 Antibody

Binding Specificity: AA 110-199

Purpose: C9orf72 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human C9orf72 (AA: 110-199) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for C9ORF72

Target: C9ORF72 (Chromosome 9 Open Reading Frame 72 (C9ORF72))

Alternative Name: C9orf72

Background: The protein encoded by this gene plays an important role in the regulation of endosomal trafficking, and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778, 21944779). Studies suggest that hexanucleotide expansions could result in the selective stabilization of repeat-containing pre-mRNA, and the accumulation of insoluble dipeptide repeat protein aggregates that could be pathogenic in FTD-ALS patients (PMID: 23393093). Alternative splicing results in multiple transcript variants encoding different isoforms.

Molecular Weight: 54.3 kDa

UniProt: Q96LT7