ICAM2 antibody (FITC)

Catalog No. ABIN7540412

This Mouse Monoclonal antibody specifically detects ICAM2 in FACS. It exhibits reactivity toward Human.

Quick Overview for ICAM2 antibody (FITC) (ABIN7540412)

Target: ICAM2 (Intercellular Adhesion Molecule 2 (ICAM2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ICAM2 antibody is conjugated to FITC

Application: Flow Cytometry (FACS)

Clone: CBR-IC2-2

Product Details anti-ICAM2 Antibody (FITC)

Purpose: Anti-Hu CD102 FITC

Specificity: The mouse monoclonal antibody CBR-IC2/2 recognizes an extracellular epitope of CD102 (ICAM-2), an approximately 55 kDa type I transmembrane glycoprotein expressed mainly on vascular endothelial cells and folicular dendritic cells, in lower amount on lymphocytes, monocytes and platelets.

Purification: Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: Human CD102 cDNA transfected COS cells

Isotype: IgG2a

Application Details

Application Notes: Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Target Details for ICAM2

Target: ICAM2 (Intercellular Adhesion Molecule 2 (ICAM2))

Alternative Name: CD102

Background:

NCBI Full Gene Name: intercellular adhesion molecule 2

Description: CD102 / ICAM-2 (intracellular cell adhesion molecule-2), a counter receptor of LFA-1 (CD11a/CD18), is a transmembrane glycoprotein with two extracellular IgC-like domains and intracellular C-terminal tail. It is involved in lymphocyte recirculation and homing to the sites of inflammation. Through interaction with integrins it provides to the immune cells costimulatory signals. Expression of CD102 on blood cells (lymphocytes, monocytes, thrombocytes) is lower than on endothelium and follicular dendritic cells. CD102 levels are upregulated in lymph nodes with malignant infiltration.

Other names: ICAM2

Gene name: ICAM2

Gene ID: 3384

UniProt: P13598