SIGLEC9 antibody (PE)

Catalog No. ABIN7540436

This Mouse Monoclonal antibody specifically detects SIGLEC9 in FACS. It exhibits reactivity toward Human.

Quick Overview for SIGLEC9 antibody (PE) (ABIN7540436)

Target: SIGLEC9 (Sialic Acid Binding Ig-Like Lectin 9 (SIGLEC9))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SIGLEC9 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Clone: K8

Product Details anti-SIGLEC9 Antibody (PE)

Purpose: Anti-Hu CD329 PE

Specificity: The mouse monoclonal antibody K8 recognizes an extracellular epitope of CD239, a type I transmembrane glycoprotein expressed above all on monocytes, neutrophils, and a minor population of CD16+CD56- cells.

Purification: Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: recombinant CD329-Hu IgGFc fusion protein

Isotype: IgG1 kappa

Application Details

Application Notes: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Target Details for SIGLEC9

Target: SIGLEC9 (Sialic Acid Binding Ig-Like Lectin 9 (SIGLEC9))

Alternative Name: CD329

Background:

NCBI Full Gene Name: sialic acid binding Ig like lectin 9

Description: CD329 is a type I transmembrane glycoprotein of siglec family, which contains intracellular ITIM motif, and a SLAM-like motif, that acts as a docking site for SAP. CD329 can regulate TCR signaling by recruitment of SHP-1, which results in down-regulation of TCR-based gene transcription. It is expressed above all on monocytes, neutrophils, and a minor population of CD16+CD56- cells, weaker expression is detectable in some B cells, NK cells, and T cells.

Other names: SIGLEC9

Gene name: SIGLEC9

Gene ID: 27180

UniProt: Q9Y336