CD38 antibody (FITC)

Catalog No. ABIN7540444

This anti-CD38 antibody is a Mouse Monoclonal antibody detecting CD38 in FACS, WB and ICC. Suitable for Human.

Quick Overview for CD38 antibody (FITC) (ABIN7540444)

Target: CD38

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD38 antibody is conjugated to FITC

Application: Flow Cytometry (FACS), Western Blotting (WB), Immunocytochemistry (ICC)

Clone: HB7

Product Details anti-CD38 Antibody (FITC)

Purpose: Anti-Hu CD38 FITC

Specificity: The mouse monoclonal antibody HB7 (HB-7) recognizes an extracellular epitope within amino acids 273-285 of human CD38, a 45 kDa type II transmembrane glycoprotein strongly expressed mainly on plasma cells and activated T and B lymphocytes, it is an antigenic marker of lymphoid cells. Its binding is blocked by daratumumab.

Purification: Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: BJAB cell line

Isotype: IgG1 kappa

Application Details

Application Notes: Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Target Details for CD38

Target: CD38

Background:

NCBI Full Gene Name: CD38 Molecule

Description: CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. Another role of CD38 is provided by enzymatic activity of its extracellular part. CD38 acts as NAD+ glycohydrolase converting NAD+ into ADP-ribose, as ADP-ribosyl cyclase producing cADPR and as cADPR hydrolase, thus affecting levels of calcium-mobilizing metabolites. ADPR produced by CD38 serves as an important second messenger of neutrophil and dendritic cell migration. CD38 belongs to markers of B cell subsets, leukemia, and a target of immunotherapy in myeloma treatment.

Other names: ADPRC1, cADPr hydrolase 1, T10, NAD(+) nucleosidase, ADP-ribosyl cyclase 1

Gene name: CD38

Gene ID: 952

UniProt: P28907