ITGA5 antibody (PE)

Catalog No. ABIN7540446

The Mouse Monoclonal anti-ITGA5 antibody has been validated for FACS. It is suitable to detect ITGA5 in samples from Human and Non-Human Primate.

Quick Overview for ITGA5 antibody (PE) (ABIN7540446)

Target: ITGA5 (Integrin, alpha 5 (ITGA5))

Reactivity: Human, Non-Human Primate

Host: Mouse

Clonality: Monoclonal

Conjugate: This ITGA5 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Clone: SAM1

Product Details anti-ITGA5 Antibody (PE)

Purpose: Anti-Hu CD49e PE

Specificity: The mouse monoclonal antibody SAM1 recognizes an extracellular epitope of CD49e (integrin 5 alpha), a transmembrane glycoprotein expressed on thymocytes, early and activated B cells, monocytes, NK cells, dendritic cells, osteoblast and endothelial cells.

Purification: Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: U937 cells

Isotype: IgG2b

Application Details

Application Notes: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Target Details for ITGA5

Target: ITGA5 (Integrin, alpha 5 (ITGA5))

Alternative Name: CD49e

Background:

NCBI Full Gene Name: integrin subunit alpha 5

Description: CD49e (VLA5 alpha) is a type I transmembrane glycoprotein of the integrin alpha subclass (intergrin 5 alpha), expressed on thymocytes, early and activated B cells, monocytes, NK cells, dendritic cells, osteoblast and endothelial cells. It binds to RGD sequence in fibronectin and to neural adhesion molecule L1. CD49e interactions are important for maintaining the integrity of the endothelial monolayer, as well as it is involved in monocyte migration, T cell costimulation, regulation of cell survival, and other.

Other names: VLA5 alpha, integrin 5 alpha, FNRA

Gene name: ITGA5

Gene ID: 3678

UniProt: P08648

Pathways: Integrin Complex