Recombinant CD33 (Gemtuzumab Biosimilar) antibody
Quick Overview for Recombinant CD33 (Gemtuzumab Biosimilar) antibody (ABIN7542953)
Target
Antibody Type
Reactivity
Host
Clonality
Conjugate
Application
Clone
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Purpose
- Anti-CD33 [hP67.6 (Gemtuzumab)], Mouse IgG1, kappa
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Specificity
- Recognises human CD33.
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Characteristics
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Original Species of Ab: Human
Original Format of Ab: IgG4
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Purification
- Protein A affinity purified
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Immunogen
- Gemtuzumab was generated by huminization of the murine P67.6 clone, raised against CD33-transfected FMY9S5 cells of human origin. CD33 is a transmembrane receptor expressed on predominantly on cells of the myeloid lineage, but it can also be found on some lymphoid cells.
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Isotype
- IgG1 kappa
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anti-CD33 (Gemtuzumab Biosimilar) antibody
Research Grade Reactivity: Human FACS Host: Humanized Monoclonal unconjugated Recombinant Antibody
anti-CD33 (Gemtuzumab Biosimilar) antibodyReactivity: Human FACS, IF Host: Rabbit Chimeric HP67-6 unconjugated Recombinant Antibody
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Application Notes
- A human IgG4 variant conjugated to derivative of the cytotoxic drug calicheamicin gamma 1, N-acetylcalicheamicin dimethyl hydrazide, has been used as a therapeutic against acute myeloid leukemia. This antibody may also be used in flow cytometry and immunofluorescence.
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Comment
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This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG4 format, for improved compatibility with existing reagents, assays and techniques.
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Restrictions
- For Research Use only
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Concentration
- 1 mg/mL
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Buffer
- PBS with 0.02 % Proclin 300.
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Preservative
- ProClin
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Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- 4 °C,-20 °C
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Storage Comment
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- CD33 (Gemtuzumab Biosimilar)
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Target Type
- Biosimilar
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Background
- Siglec-3
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UniProt
- P20138
Target
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