Recombinant CD40L (Ruplizumab Biosimilar) antibody

Catalog No. ABIN7542960

The Mouse Chimeric anti-CD40L (Ruplizumab Biosimilar) antibody has been validated for FACS, WB and BR. It is suitable to detect CD40L (Ruplizumab Biosimilar) in samples from Human.

Quick Overview for Recombinant CD40L (Ruplizumab Biosimilar) antibody (ABIN7542960)

Target: CD40L (Ruplizumab Biosimilar) (CD40LG (Ruplizumab Biosimilar))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Chimeric

Conjugate: This CD40L (Ruplizumab Biosimilar) antibody is un-conjugated

Application: Flow Cytometry (FACS), Western Blotting (WB), Blocking Reagent (BR)

Clone: Hu5c8

Product Details anti-CD40L (Ruplizumab Biosimilar) Antibody

Purpose: Anti-CD40L [hu5c8 (Ruplizumab)], Mouse IgG2a, kappa

Specificity: The antibody binds to CD40L with an IC50 of 0.845 μg/mL.

Characteristics:

Original Species of Ab: Human

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Immunogen: Human CD40L

Isotype: IgG2a kappa

Application Details

Application Notes: The antibody binds specifically to CD40L, a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. The antibody neutralises CD40L function, as it blocks the interaction between CD40 and CD40L. When injected into cynomolgus monkeys, the original therapeutic antibody was found to have a T1/2 of 531 ± 155 hours.

Comment:

This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for CD40L (Ruplizumab Biosimilar)

Target: CD40L (Ruplizumab Biosimilar) (CD40LG (Ruplizumab Biosimilar))

Alternative Name: CD40L (Ruplizumab Biosimilar)

Target Type: Biosimilar

Background: CD154, CD40 ligand, tumour necrosis factor ligand superfamily member 5, TNFSF5, tumour necrosis factor related activation protein, TRAP

UniProt: P29965