Recombinant TCR beta antibody

Catalog No. ABIN7543083

The Rabbit Chimeric anti-TCR beta antibody has been validated for FACS, IF and ELISA. It is suitable to detect TCR beta in samples from Human.

Quick Overview for Recombinant TCR beta antibody (ABIN7543083)

Target: TCR beta (T Cell Receptor (TCR) beta (TCR beta))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Chimeric

Conjugate: This TCR beta antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunofluorescence (IF), ELISA

Clone: IARC307

Product Details anti-TCR beta Antibody

Purpose: Anti-TCR beta [IARC307], Rabbit IgG, kappa

Specificity: This antibody is specific for Vbeta8.1 CDR1 sequence CKPISGHNSLFQWYRQT.

Characteristics:

Original Species of Ab: Human

Original Format of Ab: IgM

Purification: Protein A affinity purified

Immunogen: Derived from normal B cells in peripheral blood of a Burkitt's lymphoma patient. Screened more than 60 culture supernatants from lymphoblastoid cell lines of normal origin, Epstein-Barr virus (EBV)-carrying Burkitt lymphomas, EBV-negative Burkitt lymphomas and EBV-converted sublines of original EBV-negative Burkitt lymphoma human B-cell lines for their capacity to bind the synthetic peptide autoantigens. One lymphoblastoid B-cell line was identified, IARC307, that produces IgM kappa antibodies which specifically react with the CDR1 peptide corresponding to human Vbeta8.1 gene sequence.

Isotype: IgG kappa

Application Details

Application Notes: IARC307 has been used in ELISAs to bind to synthetic peptides of CRD1 region from several TCR Vbeta families of man and mouse (Marchalonis 2000).

Comment:

This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgM format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for TCR beta

Target: TCR beta (T Cell Receptor (TCR) beta (TCR beta))

Alternative Name: TCR beta

Background: IARC-307, TCR-beta, T cell receptor, T-cell receptor, T cell receptor beta chain, TCRB, TRB, TCB1, Ti, TCR V beta, IARC/307, IARC 307

UniProt: P01850, A0A5B9