Recombinant CD20 antibody

Catalog No. ABIN7543144

This anti-CD20 antibody is a Rabbit Chimeric antibody detecting CD20 in ELISA. Suitable for Dog.

Quick Overview for Recombinant CD20 antibody (ABIN7543144)

Target: CD20 (MS4A1) (Membrane-Spanning 4-Domains, Subfamily A, Member 1 (MS4A1))

Antibody Type: Recombinant Antibody

Reactivity: Dog

Host: Rabbit

Clonality: Chimeric

Conjugate: This CD20 antibody is un-conjugated

Application: ELISA

Clone: RF2

Product Details anti-CD20 Antibody

Purpose: Anti-CD20 [RF2], Rabbit IgG, kappa

Specificity: This antibody recognizes and binds an extracellular epitope containing amino acid sequence 'SEKNS' of the canine CD20. This antibody can also bind human, murine and feline cyclic CD20 peptides.

Cross-Reactivity: Cat, Human, Mouse

Characteristics:

Original Species of Ab: Mouse

Original Format of Ab: IgG2a

Purification: Protein A affinity purified

Immunogen: The original antibody was generated by immunizing mice with cyclic canine CD20 peptide.

Isotype: IgG kappa

Application Details

Application Notes: CD20 is an established marker or target for B-cell lymphomas due to the expression of this antigen at high levels on malignant B cells which are associated with B cell lymphoma. This antibody is recommended for diagnosis and may be used for treatment of lymphomas and other immune mediated diseases in dogs and cats. RF2 is capable of binding canine, feline, murine and human CD20 in an ELISA (US20140294819). This antibody is also available in caninized and felinized versions on request.

Comment:

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for CD20

Target: CD20 (MS4A1) (Membrane-Spanning 4-Domains, Subfamily A, Member 1 (MS4A1))

Alternative Name: CD20

Background: B-lymphocyte antigen CD20, Membrane-spanning 4-domains subfamily A member 1, MS4A1

UniProt: Q3C2E2