Recombinant beta Catenin antibody
Quick Overview for Recombinant beta Catenin antibody (ABIN7543332)
Target
See all beta Catenin (CATNB) AntibodiesAntibody Type
Reactivity
Host
Clonality
Conjugate
Application
Clone
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Purpose
- Anti-B-catenin [3B1D11A8], Rabbit IgG, kappa
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Specificity
- This antibody binds human beta-catenin. The human β-catenin acts as a multi-functional protein that plays a very important role in cell adhesion and Wnt signaling pathway mediated gene expression regulation. Β-catenin on the cell membrane can be combined with the cytoplasmic domain of E-Cadherin (E-CAD) to form an e-cadherin / β-catenin complex, which mediates mutual adhesion between the same type. It acts as a key regulatory molecule in the Wnt signaling pathway and plays an important role in the occurrence / evolution of the embryonic development and tumor.
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Characteristics
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Original Species of Ab: Mouse
Original Format of Ab: IgG1
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Purification
- Protein A affinity purified
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Immunogen
- The original antibody was generated by immunizing BALB/c mice with human beta-catenin-KLH conjugate in Freund's non-complete adjuvant.
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Isotype
- IgG kappa
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anti-Catenin, beta (CATNB) (pSer33), (pSer37) antibody
CATNB Reactivity: Human, Mouse, Rat WB, FACS, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Catenin, beta (CATNB) (AA 661-781) antibodyCATNB Reactivity: Human, Mouse, Rat, Pig, Zebrafish (Danio rerio) WB, FACS, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Catenin, beta (CATNB) (C-Term) antibodyCATNB Reactivity: Human, Mouse, Rat, Chicken, Cow, Dog, Pig, Rabbit, Sheep, Monkey, Hamster, Avian, Cat, Donkey, Goat, Guinea Pig, Horse WB, IF Host: Goat Polyclonal unconjugated
anti-Catenin, beta (CATNB) (C-Term) antibodyCATNB Reactivity: Human, Zebrafish (Danio rerio) WB, IHC, ELISA Host: Rabbit Polyclonal unconjugated
anti-Catenin, beta (CATNB) (pSer33), (pSer37), (pThr41) antibodyCATNB Reactivity: Human, Mouse, Rat WB, IHC Host: Rabbit Polyclonal unconjugated
anti-Catenin, beta (CATNB) (AA 439-675) antibodyCATNB Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Catenin, beta (CATNB) (AA 439-675) antibodyCATNB Reactivity: Human WB, IHC, IP, ICC Host: Mouse Monoclonal C11 unconjugated
anti-Catenin, beta (CATNB) antibodyCATNB Reactivity: Human, Mouse, Hamster WB, IP, ICC, ICFC Host: Mouse Monoclonal EM-22 unconjugated
anti-Catenin, beta (CATNB) antibodyCATNB Reactivity: Human, Mouse, Rat WB, IHC Host: Mouse Monoclonal 4A3H3 unconjugated
anti-Catenin, beta (CATNB) (AA 764-781) antibodyCATNB Reactivity: Human, Mouse, Rat WB, IHC (p), ICC, IHC (fro) Host: Rabbit Polyclonal unconjugated
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Application Notes
- The binding characterization of this antibody was done using ELISA. The original mouse IgG1 antibody binds human B-catenin with an affinity constant of 4.96 X 10^(9) M^(-1). This antibody was also used in the immunohistochemical analysis of colorectal carcinoma and pancreatic cancer tissues. The immunohistochemical staining pattern of this antibody is similar to commercially available antibody CAT-5H10 (CN112457400).
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Comment
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This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.
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Restrictions
- For Research Use only
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Concentration
- 1 mg/mL
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Buffer
- PBS with 0.02 % Proclin 300.
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Preservative
- ProClin
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Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- 4 °C,-20 °C
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Storage Comment
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- beta Catenin (CATNB) (Catenin, beta (CATNB))
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Alternative Name
- B-catenin
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Background
- CTNNB1, CTNNB, Catenin beta-1, Beta-catenin, CAT-5H10, CGMCC No. 19685
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UniProt
- P35222
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Pathways
- Peptide Hormone Metabolism
Target
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