Recombinant FcRn antibody

Catalog No. ABIN7543364

This Rabbit Chimeric antibody specifically detects FcRn in BP, in vitro and in vivo. It exhibits reactivity toward Human.

Quick Overview for Recombinant FcRn antibody (ABIN7543364)

Target: FcRn (neonatal Fc Receptor (FcRn))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Chimeric

Conjugate: This FcRn antibody is un-conjugated

Application: Blocking Peptide (BP), In vitro Assay (in vitro), In vivo Studies (in vivo)

Clone: H22-0015

Product Details anti-FcRn Antibody

Purpose: Anti-FcRn [h22-0015], Rabbit IgG, kappa

Specificity: The antibody is specific for human FcRn. The neonatal Fc receptor is a cell surface receptor that transfers passive humoral immunity from the mother to the newborn.

Characteristics:

Original Species of Ab: Mouse

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Immunogen: The original antibody was generated by immunizing Balb/c mice with recombinant FcRn.

Isotype: IgG kappa

Application Details

Application Notes: The antibody was employed in blocking experiments with HEK293 cells that overexpress FcRn. The results showed that the antibody has a good effect of blocking the binding of IgG to FcRn at the cellular level (IC50: 11.4nM). The effect of the antibody was tested in human FcRn transgenic mice. The antibody was able to increase IgG catabolism in vivo by blocking FcRn binding (CN113484526).

Comment:

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for FcRn

Target: FcRn (neonatal Fc Receptor (FcRn))

Alternative Name: FcRn

Background: IgG receptor FcRn large subunit p51, FCGRT, IgG Fc fragment receptor transporter alpha chain, Neonatal Fc receptor

UniProt: P55899

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process