Recombinant Ferritin antibody

Catalog No. ABIN7543450

The Mouse Monoclonal anti-Ferritin antibody (Clone AMB8LK) (ABIN7543450) specifically detects Ferritin in IP. The antibody is reactive with Human samples.

Quick Overview for Recombinant Ferritin antibody (ABIN7543450)

Target: Ferritin (FE)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Ferritin antibody is un-conjugated

Application: Immunoprecipitation (IP)

Clone: AMB8LK

Product Details anti-Ferritin Antibody

Purpose: Anti-Ferritin [AMB8LK], Mouse IgG1, kappa

Specificity: This antibody binds human ferritin. This protein catalyzes the oxidation of ferrous iron(II) to ferric iron(III) and stores iron in a soluble, non-toxic, readily available form. Ferritin is important for iron homeostasis.

Characteristics:

Original Species of Ab: Mouse

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Immunogen: The original antibody was generated by immunizing female Balb/c mice with ferritin extracted from human spleen cells.

Isotype: IgG1 kappa

Application Details

Application Notes: This antibody was capable of immunoprecipitating ferritin (PMID: 6817879). The original antibody binds human ferritin with a binding affinity of Kd= 5.1nM (EP2193147). The thiolated version of this antibody was conjugated to maleimide-activated polylactide nanoparticles (NPs) to generate immunonanoparticles, which may carry drugs to desired overexpressing antigen cells potentially leading to improved drug therapy and reduced systemic adverse effects (PMID: 19835957). Preclinical studies showed that the immunoconjugate with 90Y has 98 % stability over 7 days. A very good pancreatic adenocarcinoma tumor targeting was observed especially with the Bz-DTPA-AMB8LK (PMID: 17383579)

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for Ferritin

Target: Ferritin (FE)

Alternative Name: Ferritin

Background: FTMT, FTL, FTH1, Ferritin mitochondrial, B8

UniProt: Q8N4E7

Pathways: Transition Metal Ion Homeostasis