Recombinant Ferritin antibody
FE
Reactivity: Human
IP
Host: Mouse
Monoclonal
AMB8LK
unconjugated
Recombinant Antibody
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- Target See all Ferritin (FE) Antibodies
- Ferritin (FE)
- Antibody Type
- Recombinant Antibody
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This Ferritin antibody is un-conjugated
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Application
- Immunoprecipitation (IP)
- Purpose
- Anti-Ferritin [AMB8LK], Mouse IgG1, kappa
- Specificity
- This antibody binds human ferritin. This protein catalyzes the oxidation of ferrous iron(II) to ferric iron(III) and stores iron in a soluble, non-toxic, readily available form. Ferritin is important for iron homeostasis.
- Characteristics
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Original Species of Ab: Mouse
Original Format of Ab: IgG1
- Purification
- Protein A affinity purified
- Immunogen
- The original antibody was generated by immunizing female Balb/c mice with ferritin extracted from human spleen cells.
- Clone
- AMB8LK
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product FE Primary Antibody
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anti-Ferritin (FE) antibody
FE Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
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- Application Notes
- This antibody was capable of immunoprecipitating ferritin (PMID: 6817879). The original antibody binds human ferritin with a binding affinity of Kd= 5.1nM (EP2193147). The thiolated version of this antibody was conjugated to maleimide-activated polylactide nanoparticles (NPs) to generate immunonanoparticles, which may carry drugs to desired overexpressing antigen cells potentially leading to improved drug therapy and reduced systemic adverse effects (PMID: 19835957). Preclinical studies showed that the immunoconjugate with 90Y has 98 % stability over 7 days. A very good pancreatic adenocarcinoma tumor targeting was observed especially with the Bz-DTPA-AMB8LK (PMID: 17383579)
- Restrictions
- For Research Use only
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- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % Proclin 300.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- Target
- Ferritin (FE)
- Alternative Name
- Ferritin (FE Products)
- Background
- FTMT, FTL, FTH1, Ferritin mitochondrial, B8
- UniProt
- Q8N4E7
- Pathways
- Transition Metal Ion Homeostasis
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