ACE2 antibody (Atto 488)

Catalog No. ABIN7566403

This Mouse Monoclonal antibody specifically detects ACE2 in FACS. It exhibits reactivity toward Human.

Quick Overview for ACE2 antibody (Atto 488) (ABIN7566403)

Target: ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ACE2 antibody is conjugated to Atto 488

Application: Flow Cytometry (FACS)

Clone: AC18F

Product Details anti-ACE2 Antibody (Atto 488)

Purpose: anti-ACE2 (human), mAb (AC18F) (ATTO 488)

Characteristics:

Monoclonal Antibody. Recognizes human ACE2. Application: ELISA, FACS, WB. Clone: AC18F. Isotype: Mouse IgG1κ. Liquid. In PBS. Angiotensin-converting enzyme2 (ACE2) is an ectoenzyme (carboxypeptidase) with an extracellular catalytic domain that predominantly localizes at the plasma membrane and is thereby able to hydrolyze circulating peptides. ACE2 has approximately 42 % sequence identity with ACE, and its cytoplasmic and transmembrane domains show 48 % homology to the protein collectrin that plays a critical role in the amino acid absorption of the kidney. ACE2 converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. ACE2 is involved in the regulation of systemic blood pressure and has direct effects on cardiac functions. It is expressed predominantly in endothelial cells of the lung, gut, heart and kidney. ACE2 together with the protease TMPRSS2 acts as a functional receptor for SARS coronavirus as well as for the new highly pathogenic coronavirus, 2019-nCoV/SARS-CoV-2, which is cause for pneumonia COVID-19.

Angiotensin-converting enzyme2 (ACE2) is an ectoenzyme (carboxypeptidase) with an extracellular catalytic domain that predominantly localizes at the plasma membrane and is thereby able to hydrolyze circulating peptides. ACE2 has approximately 42 % sequence identity with ACE, and its cytoplasmic and transmembrane domains show 48 % homology to the protein collectrin that plays a critical role in the amino acid absorption of the kidney. ACE2 converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. ACE2 is involved in the regulation of systemic blood pressure and has direct effects on cardiac functions. It is expressed predominantly in endothelial cells of the lung, gut, heart and kidney. ACE2 together with the protease TMPRSS2 acts as a functional receptor for SARS coronavirus as well as for the new highly pathogenic coronavirus, 2019-nCoV/SARS-CoV-2, which is cause for pneumonia COVID-19.

Immunogen: Recombinant human ACE2.

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: In PBS.

Handling Advice: Do not freeze.Protect from light.

Storage: 4 °C

Storage Comment:

Keep conjugated formats at +4°C. Stable for at least 1 year after receipt when stored at +4°C.

Target Details for ACE2

Target: ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))

Alternative Name: ACE2

Pathways: ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour