LTBR antibody

Catalog No. ABIN7566478

This Rat Monoclonal antibody specifically detects LTBR in FACS and Func. It exhibits reactivity toward Mouse.

Quick Overview for LTBR antibody (ABIN7566478)

Target: LTBR (Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This LTBR antibody is un-conjugated

Application: Flow Cytometry (FACS), Functional Studies (Func)

Clone: 4H8 WH2

Product Details anti-LTBR Antibody

Purpose: anti-LTβR (mouse), mAb (4H8 WH2) (preservative free)

Characteristics:

Monoclonal Antibody. Recognizes mouse LTbetaR. Isotype: Rat IgG2a. Clone: 4H8 WH2. Applications: FACS, FUNC (Blocking). Liquid. In PBS containing 10 % glycerol. The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.

The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.

Purification: Puified

Purity: >95 % (SDS-PAGE)

Immunogen: Recombinant mouse LTbetaR (cysteine-rich region/aa 31-221).

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: In PBS containing 10 % glycerol.

Preservative: Without preservative

Handling Advice: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment:

+4°C

Stable for at least 1 year after receipt when stored at -20°C.

Target Details for LTBR

Target: LTBR (Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR))

Alternative Name: LtbetaR

UniProt: P50284

Pathways: NF-kappaB Signaling