Recombinant CRP antibody

Catalog No. ABIN7581768

The Mouse Monoclonal anti-CRP antibody has been validated for ELISA. It is suitable to detect CRP in samples from Human.

Quick Overview for Recombinant CRP antibody (ABIN7581768)

Target: CRP (C-Reactive Protein (CRP))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CRP antibody is un-conjugated

Application: ELISA

Grade: Animal-Free

Clone: AB469-1-A05

Product Details anti-CRP Antibody

Expression System: Phage display

Purpose: Mouse Anti- human C-reactive protein (CRP)

Specificity: This is an antibody developed by antibody phage display technology using a human naive antibody gene library and human C-reactive protein (CRP) antigen. For this antibody both the heavy and light chains are cloned and expressed, generating full-length antibodies.

Characteristics: This antibody can be detected with anti-mouse Fc secondary antibodies.

Purification: Protein A purification

Immunogen: No immunization, animal-free antibody development. Antigen: human C-reactive protein

Isotype: IgG2a

Application Details

Application Notes: ELISA: 1-12 μg/mL as coating antibody 0.5-5 μg/mL as detection antibody Optimal working dilution should be determined by the investigator

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, pH 7.4,

Storage: -20 °C

Target Details for CRP

Target: CRP (C-Reactive Protein (CRP))

Alternative Name: C-reactive Protein

Background: C-reactive protein (CRP) is an important acute-phase protein produced by the liver in response to inflammation, primarily triggered by the cytokine interleukin-6 (IL-6). Structurally, CRP is a pentamer composed of five identical subunits, which enables it to bind to phosphocholine on the surfaces of dead or dying cells and certain bacteria. This binding facilitates the activation of the complement system and enhances phagocytosis, playing a crucial role in the innate immune response. Clinically, elevated CRP levels in the blood serve as a non-specific marker of inflammation, making it useful for diagnosing and monitoring conditions such as infections, autoimmune disorders, and inflammatory diseases like rheumatoid arthritis and inflammatory bowel disease (IBD). High-sensitivity CRP (hs-CRP) tests are also utilized to assess the risk of cardiovascular diseases, including heart attacks and strokes, by detecting low levels of chronic inflammation. In summary, C-reactive protein is a key indicator of inflammation and immune system activity, widely used in medical diagnostics to evaluate and monitor various inflammatory and infectious conditions.

Molecular Weight: 115 kDa

Gene ID: 1401

NCBI Accession: NG_013007

UniProt: P02741

Pathways: Carbohydrate Homeostasis